Paisley Museum will undergo a £42m transformation beginning in 2020 after plans were approved by Renfrewshire Council.
The Category A-listed Victorian building is being upgraded to help it tell the stories of a town known around the world for its pattern.
The museum is expected to draw audiences of 125,000 people a year - almost four times current numbers - from Scotland, the rest of the UK and internationally when it is due to reopen in 2022.
The designs have been produced by AL_A, a company headed by by Stirling Prize winner Amanda Levete.
The Paisley Museum Reimagined scheme is the flagship project within Renfrewshire Council's £100m investment in cultural venues and outdoor spaces.
Councillor Marie McGurk, convener of Renfrewshire Council's communities, housing and planning board, said: "The designs which have been produced blend the old and the new - they will create a 21st-century visitor experience while preserving a key part of our fantastic architectural legacy, and ensure this much-loved building can stay at the heart of life in the area for generations to come.
"Paisley's name is already known around the world - and when the museum reopens in 2022 it will allow us to invite the world to come back to Paisley, providing new opportunities, life and footfall for the town centre and wider Renfrewshire area."
The project is expected to create a £79m boost for the local economy over 30 years, with 138 jobs supported during construction, and almost 50 jobs per year through revenue and visitor spending.
Image: Paisley Museum